Salivary DNA Methylation as an Epigenetic Biomarker for Head and Neck Cancer. Part II: A Cancer Risk Meta-Analysis

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ID: 267485
2021
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Aberrant methylation of tumor suppressor genes has been reported as an important epigenetic silencer in head and neck cancer (HNC) pathogenesis. Here, we performed a comprehensive meta-analysis to evaluate the overall and specific impact of salivary gene promoter methylation on HNC risk. The methodological quality was assessed using the Newcastle–Ottawa scale (NOS). Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the association and Egger’s and Begg’s tests were applied to detect publication bias. The frequency of salivary DNA promoter methylation was significantly higher in HNC patients than in healthy controls (OR: 8.34 (95% CI = 6.10–11.39; p < 0.01). The pooled ORs showed a significant association between specific tumor-related genes and HNC risk: p16 (3.75; 95% CI = 2.51–5.60), MGMT (5.72; 95% CI = 3.00–10.91), DAPK (5.34; 95% CI = 2.18–13.10), TIMP3 (3.42; 95% CI = 1.99–5.88), and RASSF1A (7.69; 95% CI = 3.88–15.23). Overall, our meta-analysis provides precise evidence on the association between salivary DNA promoter hypermethylation and HNC risk. Thus, detection of promoter DNA methylation in saliva is a potential biomarker for predicting HNC risk.
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Authors Óscar Rapado-González;Cristina Martínez-Reglero;Ángel Salgado-Barreira;María Arminda Santos;Rafael López-López;Ángel Díaz-Lagares;María Mercedes Suárez-Cunqueiro;Rapado-González, Óscar;Martínez-Reglero, Cristina;Salgado-Barreira, Ángel;Santos, María Arminda;López-López, Rafael;Díaz-Lagares, Ángel;Suárez-Cunqueiro, María Mercedes;
Journal Journal of personalized medicine
Year 2021
DOI 10.3390/jpm11070606
URL
https://www.mdpi.com/2075-4426/11/7/606/htm
Keywords
meta-analysis biomarkers dna methylation epigenetics head and neck cancer saliva liquid biopsy

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