Monitoring FoxO1 localization in chemically identified neurons

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2008
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The PI3K-Akt-FoxO1 pathway contributes to the actions of insulin and leptin in several cell types, including neurons in the CNS. However, identifying these actions in chemically identified neurons has proven difficult. To address this problem, we have developed a reporter mouse for monitoring PI3K-A …
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Authors Fukuda M;Jones JE;Olson D;Hill J;Lee CE;Gautron L;Choi M;Zigman JM;Lowell BB;Elmquist JK;;
Journal The Journal of neuroscience : the official journal of the Society for Neuroscience
Year 2008
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/19074037
Keywords
image processing National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't N.I.H. Extramural Proto-Oncogene Proteins c-akt / metabolism Fatty Acids in situ hybridization organ culture techniques immunohistochemistry computer-assisted green fluorescent proteins / genetics insulin / metabolism leptin / metabolism signal transduction / physiology* neurons / metabolism* phosphatidylinositol 3-kinases / metabolism pmid:19074037 pmc2615536 doi:10.1523/jneurosci.4023-08.2008 makoto fukuda juli e jones joel k elmquist nonesterified / metabolism forkhead box protein o1 forkhead transcription factors / genetics forkhead transcription factors / metabolism* gene knock-in techniques green fluorescent proteins / metabolism* hypothalamus / metabolism

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