Association of the APC gene product with beta-catenin

Clicks: 272
ID: 267097
1993
Mutations in the human APC gene are linked to familial adenomatous polyposis and to the progression of sporadic colorectal and gastric tumors. To gain insight into APC function, APC-associated proteins were identified by immunoprecipitation experiments. Antibodies to APC precipitated a 95-kilodalton …
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Authors Rubinfeld B;Souza B;Albert I;Müller O;Chamberlain SH;Masiarz FR;Munemitsu S;Polakis P;;
Journal Science (New York, N.Y.)
Year 1993
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8259518
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't amino acid sequence Antibodies Cultured cell line Genes Molecular Sequence Data cell adhesion tumor cells colonic neoplasms / genetics precipitin tests colonic neoplasms / metabolism* trans-activators* beta catenin cytoskeletal proteins / metabolism* pmid:8259518 doi:10.1126/science.8259518 b rubinfeld b souza p polakis adenomatous polyposis coli protein cadherins / metabolism* cytoskeletal proteins / chemistry cytoskeletal proteins / isolation & purification apc* neoplasm proteins / genetics neoplasm proteins / immunology neoplasm proteins / metabolism*

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