BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling

Clicks: 259
ID: 266773
2004
In humans, mutations in BMPR1A, SMAD4 and PTEN are responsible for juvenile polyposis syndrome, juvenile intestinal polyposis and Cowden disease, respectively. The development of polyposis is a common feature of these diseases, suggesting that there is an association between BMP and PTEN pathways. T …
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Authors He XC;Zhang J;Tong WG;Tawfik O;Ross J;Scoville DH;Tian Q;Zeng X;He X;Wiedemann LM;Mishina Y;Li L;;
Journal nature genetics
Year 2004
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/15378062
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice Inbred C57BL animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't Disease Models Animal Receptors transgenic stem cells / cytology signal transduction pmid:15378062 doi:10.1038/ng1430 xi c he jiwang zhang linheng li adenomatous polyposis coli / etiology adenomatous polyposis coli / genetics bone morphogenetic protein receptors type i bone morphogenetic proteins / physiology* cytoskeletal proteins / physiology* epithelial cells / pathology intestines / cytology* mutant strains pten phosphohydrolase protein tyrosine phosphatases / physiology protein-serine-threonine kinases / genetics protein-serine-threonine kinases / physiology proto-oncogene proteins / physiology* proto-oncogene proteins c-akt growth factor / genetics growth factor / physiology trans-activators / physiology* tumor suppressor proteins / physiology wnt proteins beta catenin

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