SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene

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ID: 266238
1993
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Abstract
Sterol regulatory element 1 (SRE-1), a decamer (5'-ATC-ACCCCAC-3') flanking the low density lipoprotein (LDL) receptor gene, activates transcription in sterol-depleted cells and is silenced by sterols. We report the cDNA cloning of human SREBP-1, a protein that binds SRE-1, activates transcription, ā€¦
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Authors Yokoyama C;Wang X;Briggs MR;Admon A;Wu J;Hua X;Goldstein JL;Brown MS;;
Journal Cell
Year 1993
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/8402897
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE genetic Molecular RNA humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't amino acid sequence Comparative Study P.H.S. DNA x wang DNA-Binding Proteins / metabolism* Nuclear Proteins / metabolism* Receptors Base Sequence Molecular Sequence Data DNA-Binding Proteins / biosynthesis Gene Expression Regulation* Nuclear Proteins / biosynthesis Messenger / biosynthesis transcription messenger / metabolism sequence homology amino acid nucleic acid dna primers cloning recombinant proteins / biosynthesis regulatory sequences repetitive sequences hela cells dna-binding proteins / isolation & purification nuclear proteins / isolation & purification binding sites cell nucleus / metabolism transcription factors* sterol regulatory element binding protein 1 leucine zippers* recombinant proteins / metabolism ldl / genetics* pmid:8402897 c yokoyama m s brown ccaat-enhancer-binding proteins* complementary / metabolism helix-loop-helix motifs* ldl / biosynthesis* nucleic acid*

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