High dose of plasmid IL-15 inhibits immune responses in an influenza non-human primates immunogenicity model

Clicks: 277
ID: 265981
2009
Interleukin (IL)-15, is a cytokine that is important for the maintenance of long-lasting, high-avidity T cell response to invading pathogens and has, therefore, been used in vaccine and therapeutic platforms as an adjuvant. In addition to pure protein delivery, plasmids encoding the IL-15 gene have …
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Authors Yin J;Dai A;Laddy DJ;Yan J;Arango T;Khan AS;Lewis MG;Andersen H;Kutzler MA;Draghia-Akli R;Weiner DB;Boyer JD;;
Journal Virology
Year 2009
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/19683780
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE animals humans pubmed abstract nih national institutes of health national library of medicine research support N.I.H. Extramural Antibodies plasmids viral / blood vaccines dose-response relationship drug macaca mulatta hemagglutination inhibition tests cd8-positive t-lymphocytes / immunology cell proliferation cd4-positive t-lymphocytes / immunology intramural pmid:19683780 pmc4118595 doi:10.1016/j.virol.2009.07.017 jiangmei yin anlan dai jean d boyer influenza vaccines / genetics influenza vaccines / immunology* interferon-gamma / metabolism interleukin-15 / genetics interleukin-15 / immunology* dna / genetics dna / immunology*

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