Delayed antiviral plus immunomodulator treatment still reduces mortality in mice infected by high inoculum of influenza A/H5N1 virus

Clicks: 388
ID: 265610
2008
The mortality of human infection by influenza A/H5N1 virus can exceed 80%. The high mortality and its poor response to the neuraminidase inhibitor oseltamivir have been attributed to uncontrolled virus-induced cytokine storm. We challenged BALB/c mice with 1,000 LD50 of influenza A/Vietnam/1194/04. …
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Authors Zheng BJ;Chan KW;Lin YP;Zhao GY;Chan C;Zhang HJ;Chen HL;Wong SS;Lau SK;Woo PC;Chan KH;Jin DY;Yuen KY;;
Journal Proceedings of the National Academy of Sciences of the United States of America
Year 2008
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/18523003
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't female Inbred BALB C Survival Analysis lung / pathology time factors survival rate antiviral agents / therapeutic use* body weight / drug effects viral load antiviral agents / pharmacology influenza a virus lung / virology lymphocyte count kwok-yung yuen t-lymphocytes / drug effects pmid:18523003 pmc2430364 doi:10.1073/pnas.0711942105 bo-jian zheng kwok-wah chan albumins / metabolism chemokines / metabolism immunologic factors / pharmacology immunologic factors / therapeutic use* h5n1 subtype / drug effects h5n1 subtype / physiology* lung / drug effects orthomyxoviridae infections / drug therapy* prostaglandins / metabolism t-lymphocytes / virology

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