ATP responsive DNA nanogels grown on biocompatible branches for anticancer drug delivery.
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2019
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Abstract
We developed biocompatible ATP responsive DNA nanogels, by grafting DNA strands on carboxymethyl chitosan polymer chains, and then hybridizing with ATP aptamers to form core-shell nanogels. The DNA duplex structure could embed DOX in the G-C sequences, and realize simultaneous sol-gel transition and DOX release when suffering enrich ATP in tumor cells.Reference Key |
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Authors | Zhao, Meihui;Zhang, Yu;Yuan, Shirui;Xu, Xiang;Wu, Ziheng;Wu, Zhenghong;Qi, Xiaole; |
Journal | Soft matter |
Year | 2019 |
DOI | 10.1039/c9sm00480g |
URL | |
Keywords | Keywords not found |
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