An immune control model for viral replication in the CNS during presymptomatic HIV infection

Clicks: 334
ID: 261923
2006
The brain is targeted by human immunodeficiency virus type 1 (HIV-1) during the course of untreated infection, leading to cognitive impairment, neurological damage and HIV encephalitis (HIVE). To study early dynamics of HIV entry into the brain, we examined a unique autopsy series of samples obtaine …
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Authors McCrossan M;Marsden M;Carnie FW;Minnis S;Hansoti B;Anthony IC;Brettle RP;Bell JE;Simmonds P;;
Journal Brain
Year 2006
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/16317019
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine models research support adult female male N.I.H. Extramural amino acid sequence DNA Sequence Analysis Viral / analysis Base Sequence Molecular Sequence Data Polymerase Chain Reaction / methods proviruses / genetics hiv-1 / genetics hiv infections / immunology* cd8-positive t-lymphocytes / immunology virus replication* pmid:16317019 doi:10.1093/brain/awh695 m mccrossan m marsden p simmonds central nervous system / immunology* central nervous system / virology hiv envelope protein gp120 / analysis hiv envelope protein gp120 / genetics hiv-1 / physiology* immunohistochemistry / methods lymphoid tissue / immunology lymphoid tissue / virology immunological* peptide fragments / analysis peptide fragments / genetics proviruses / physiology*

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