Associations of Ozone and PM2.5 Concentrations With Parkinsonʼs Disease Among Participants in the Agricultural Health Study

Clicks: 409
ID: 260633
2015
Objective: This study describes associations of ozone and fine particulate matter with Parkinson's disease observed among farmers in North Carolina and Iowa. Methods: We used logistic regression to determine the associations of these pollutants with self-reported, doctor-diagnosed Parkinson's disease. Daily predicted pollutant concentrations were used to derive surrogates of long-term exposure and link them to study participants' geocoded addresses. Results: We observed positive associations of Parkinson's disease with ozone (odds ratio = 1.39; 95% CI: 0.98 to 1.98) and fine particulate matter (odds ratio = 1.34; 95% CI: 0.93 to 1.93) in North Carolina but not in Iowa. Conclusions: The plausibility of an effect of ambient concentrations of these pollutants on Parkinson's disease risk is supported by experimental data demonstrating damage to dopaminergic neurons at relevant concentrations. Additional studies are needed to address uncertainties related to confounding and to examine temporal aspects of the associations we observed.
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Authors Ellen F. Kirrane,Christal Bowman,J. Allen Davis,Jane A. Hoppin,Aaron Blair,Honglei Chen,Molini M. Patel,Dale P. Sandler,Caroline M. Tanner,Lisa Vinikoor-Imler,Mary H. Ward,Thomas J. Luben,Freya Kamel;Ellen F. Kirrane;Christal Bowman;J. Allen Davis;Jane A. Hoppin;Aaron Blair;Honglei Chen;Molini M. Patel;Dale P. Sandler;Caroline M. Tanner;Lisa Vinikoor-Imler;Mary H. Ward;Thomas J. Luben;Freya Kamel;
Journal journal of occupational and environmental medicine
Year 2015
DOI 10.1097/jom.0000000000000451
URL
https://sciprofiles.com/publication/view/f0fb0d4d8561475253a19f2b6d4f130f
Keywords
particulate matter ozone parkinson's disease fine particulate north carolina concentrations iowa

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