c-reactive protein as a mediator of complement activation and inflammatory signaling in age-related macular degeneration

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2018
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Abstract
Age-related macular degeneration (AMD) is a devastating neurodegenerative disease affecting millions worldwide. Complement activation, inflammation, and the loss of choroidal endothelial cells have been established as key factors in both normal aging and AMD; however, the exact mechanisms for these events have yet to be fully uncovered. Herein, we provide evidence that the prototypic acute phase reactant, C-reactive protein (CRP), contributes to AMD pathogenesis. We discuss serum CRP levels as a risk factor for disease, immunolocalization of distinct forms of CRP in the at-risk and diseased retina, and direct effects of CRP on ocular tissue. Furthermore, we discuss the complement system as it relates to AMD pathophysiology, provide a model for the role of CRP in this disease, and outline current therapies being developed and tested to treat AMD patients.
Reference Key
chirco2018frontiersc-reactive Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Kathleen R. Chirco;Lawrence A. Potempa
Journal sudebno-meditsinskaia ekspertiza
Year 2018
DOI 10.3389/fimmu.2018.00539
URL
http://journal.frontiersin.org/article/10.3389/fimmu.2018.00539/full
Keywords
Age-related macular degeneration inflammation c-reactive protein complement allergy

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