towards a molecular classification of colorectal cancer:the role of microsatellite instability status

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ID: 256960
2013
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Abstract
Microsatellite instability (MSI) is the molecular hallmark of DNA mismatch repair (MMR) deficiency. Since its initial description in colorectal cancer (CRC) in 1993 and its association with Lynch syndrome, the most common inherited cancer predisposition world-wide, accumulating evidence suggests that MSI status may also be of concrete prognostic and predictive value in the management of sporadic CRC. This short review aims at providing a concise survey of the molecular basis and the multifaceted role(s) of MSI status in today’s clinical practice.
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eheinimann2013frontierstowards Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Karl eHeinimann
Journal international journal of heat and technology
Year 2013
DOI 10.3389/fonc.2013.00272
URL
http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00272/full
Keywords
therapy colorectal cancer (crc) Oncology including cancer and carcinogens tumors hereditary non-polyposis colon cancer (hnpcc)neoplasms

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