alternative neural circuitry that might be impaired in the development of alzheimer disease
Clicks: 166
ID: 255934
2015
It is well established that some individuals with normal cognitive capacity have abundant senile plaques in their brains. It has been proposed that those individuals are resilient or have compensation factors to prevent cognitive decline. In this comment, we explore an alternative mechanism through which cognitive capacity is maintained. This mechanism could involve the impairment of alternative neural circuitry. Also, the proportion of molecules such as Aβ or tau protein present in different areas of the brain could be important.
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eavila2015frontiersalternative
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| Authors | ;Jesus eAvila;Jesus eAvila;George ePerry;Bryan Andrew Strange;Bryan Andrew Strange;Felix eHernandez;Felix eHernandez |
| Journal | Journal of enzyme inhibition and medicinal chemistry |
| Year | 2015 |
| DOI | 10.3389/fnins.2015.00145 |
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