identification of mouse cytomegalovirus resistance loci by enu mutagenesis
Clicks: 208
ID: 253212
2009
Host resistance to infection depends on the efficiency with which innate immune responses keep the infectious agent in check. Innate immunity encompasses components with sensing, signaling and effector properties. These elements with nonredundant functions are encoded by a set of host genes, the resistome. Here, we review our findings concerning the resistome. We have screened randomly mutagenized mice for susceptibility to a natural opportunistic pathogen, the mouse cytomegalovirus. We found that some genes with initially no obvious functions in innate immunity may be critical for host survival to infections, falling into a newly defined category of genes of the resistome.
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georgel2009virusesidentification
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| Authors | ;Philippe Georgel;Karine Crozat |
| Journal | International journal of pharmaceutics |
| Year | 2009 |
| DOI | 10.3390/v1030460 |
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