antitussive activity of the water-extracted carbohydrate polymer from terminalia chebula on citric acid-induced cough

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ID: 249821
2013
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Abstract
Terminalia chebula, a medicinal plant, is widely used in the management of various diseases. As the water extract of its dried ripe fruit is a frequently used preparation, we decided to look for bioactive polysaccharide in this extract. We demonstrate that the obtained polysaccharide fraction, CP, contained a highly branched arabinogalactan protein having a 1→3-, 1→6- and 1→3,6-linked β-D-Galp together with 1→5- and 1→3-linked α-L-Araf and nonreducing end units of α-L-Araf. This polymer possesses strong antitussive property. Our results showed that the number of citric acid-induced cough efforts decreased significantly after the oral application of polysaccharide fraction in a dose of 50 mg kg−1 body weight. Its antitussive efficacy was higher than cough suppressive effect of standard drug codeine. Therefore, traditional aqueous extraction method provides a major polysaccharide, which induces a pharmacological effect: this could represent an attractive approach in phytotherapeutic managements.
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Authors ;Gabriela Nosalova;Ludovit Jurecek;Udipta Ranjan Chatterjee;Sujay Kumar Majee;Slavomir Nosal;Bimalendu Ray
Journal ACS applied materials & interfaces
Year 2013
DOI 10.1155/2013/650134
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