antitussive activity of the water-extracted carbohydrate polymer from terminalia chebula on citric acid-induced cough
Clicks: 161
ID: 249821
2013
Article Quality & Performance Metrics
Overall Quality
Improving Quality
0.0
/100
Combines engagement data with AI-assessed academic quality
Reader Engagement
Emerging Content
30.0
/100
161 views
1 readers
Trending
AI Quality Assessment
Not analyzed
Abstract
Terminalia chebula, a medicinal plant, is widely used in the management of various diseases. As the water extract of its dried ripe fruit is a frequently used preparation, we decided to look for bioactive polysaccharide in this extract. We demonstrate that the obtained polysaccharide fraction, CP, contained a highly branched arabinogalactan protein having a 1â3-, 1â6- and 1â3,6-linked β-D-Galp together with 1â5- and 1â3-linked α-L-Araf and nonreducing end units of α-L-Araf. This polymer possesses strong antitussive property. Our results showed that the number of citric acid-induced cough efforts decreased significantly after the oral application of polysaccharide fraction in a dose of 50âmgâkgâ1 body weight. Its antitussive efficacy was higher than cough suppressive effect of standard drug codeine. Therefore, traditional aqueous extraction method provides a major polysaccharide, which induces a pharmacological effect: this could represent an attractive approach in phytotherapeutic managements.Reference Key |
nosalova2013evidence-basedantitussive
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
---|---|
Authors | ;Gabriela Nosalova;Ludovit Jurecek;Udipta Ranjan Chatterjee;Sujay Kumar Majee;Slavomir Nosal;Bimalendu Ray |
Journal | ACS applied materials & interfaces |
Year | 2013 |
DOI | 10.1155/2013/650134 |
URL | |
Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.