impact and prognostic value of 18f-fluorodeoxyglucose positron emission tomography-computed tomography scan in the evaluation of residual head and neck cancer: single-center experience from pakistan

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ID: 246882
2017
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Abstract
Background: Overview of clinical impact of positron emission tomography-computed tomography (PET-CT) scans in patients with head and neck carcinomas at our center. Methods: Retrospective review of posttreatment 18F-fluorodeoxyglucose (18F-FDG) PET-CT scans in patients with head and neck carcinomas with risk of residual disease. Clinical outcome served as the reference standard. Results: This study included 93 patients (65.6% males, mean age: 48.8 years ± 17.2 standard deviation) with squamous cell carcinoma as most frequent histopathology (91.4%). PET-CT scans were performed on average 6 months posttreatment. Diagnostic accuracy, positive predictive value, and negative predictive value of PET-CT for disease were found to be 88%, 88%, and 92%, respectively. A median follow-up of 24 months was available for 91 patients. Kaplan–Meier curves showed significantly higher disease-free survival with negative PET-CT as compared to positive PET-CT (P = 0.01) and maximum standardized uptake values of <5.0 (P = 0.01). Conclusion: FDG PET-CT has diagnostic and prognostic implications in treated patient of head and neck cancers.
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Authors ;Saima Riaz;Humayun Bashir;Hassan Iqbal;Arif Jamshed;Ahmad Murtaza;Raza Hussain
Journal cell structure and function
Year 2017
DOI 10.4103/2278-330X.208851
URL
http://journal.sajc.org/article.asp?issn=2278-330X;year=2017;volume=6;issue=2;spage=81;epage=83;aulast=Riaz
Keywords
head and neck cancer disease-free survival Oncology including cancer and carcinogens tumors squamous cell carcinomaneoplasms maximum standardized uptake values

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