insights of crosstalk between p53 protein and the mkk3/mkk6/p38 mapk signaling pathway in cancer
Clicks: 175
ID: 242499
2018
TP53 is universally recognized as a pivotal protein in cell-cycle fate and apoptotic induction and, unsurprisingly, it is one of the most commonly hijacked control mechanisms in cancer. Recently, the kinase MKK3 emerged as a potential therapeutic target in different types of solid tumor being linked to mutant p53 gain-of-function. In this review, we summarize the delicate relationship among p53 mutational status, MKK3/MKK6 and the downstream activated master kinase p38MAPK, dissecting a finely-tuned crosstalk, in a potentially cell-context dependent scenario that urges towards a deeper characterization of the different molecular players involved in this signaling cascade and their interactions.
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stramucci2018cancersinsights
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| Authors | ;Lorenzo Stramucci;Angelina Pranteda;Gianluca Bossi |
| Journal | The Journal of investigative dermatology |
| Year | 2018 |
| DOI | 10.3390/cancers10050131 |
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