deregulated levels of the nf-κb1, nf-κb2, and rel genes in ukrainian patients with leukemia and lymphoma in the post-chernobyl period
Clicks: 241
ID: 240175
2016
Objective: Nuclear factor kappa B (NF-κB) is an important
transcription factor in cancer and NF-κB activation has been seen
in angiogenesis, tumor progression, and metastasis. Relationships
between specific NF-κB gene networks, leukemogenesis, and radiation
exposure are still unknown. Our aim was to study the expression levels
of the NF-κB1, NF-κB2, and Rel genes in hematological malignancies
in the post-Chernobyl period.
Materials and Methods: We analyzed gene expression levels of NF-
κB1, NF-κB2, and Rel in 49 B-cell chronic lymphocytic leukemia, 8
B-cell non-Hodgkin’s lymphoma, 3 acute myeloid leukemia, 3 chronic
myeloid leukemia, 2 hairy cell leukemia, 2 myelodysplastic syndrome,
and 2 T-cell large granular lymphocytic leukemia patients using realtime
polymerase chain reaction.
Results: Expression levels of NF-κB1, NF-κB2, and Rel genes were
found to be deregulated.
Conclusion: These results could be accepted as specific gene traces
to radiation-induced leukemia or as potential candidates for new
diagnostic biomarker studies. Larger experiments and non-exposed
control malignant cell populations are needed to clarify these
suggestions.
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savl2016turkishderegulated
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| Authors | ;Hakan Savlı;Daniil F. Gluzman;Stella V. Koval |
| Journal | proceedings of the international conference on iot in social, mobile, analytics and cloud, i-smac 2017 |
| Year | 2016 |
| DOI | 10.4274/tjh.2014.0190 |
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| Keywords |
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