insulin resistance, atherogenic disorders and liver fibrosis in patients with metabolic syndrome

The increased interest in non-alcohol liver disease research is due to the increased incidence of obesity in developed countries. Thus liver disease is prevalent in 20-40 % of population. Nevertheless fibrosis is found not in every patient, which makes the importance to investigate the factors that are associated with fibrosis. Aim. The purpose of our research was to investigate lipid and glucose metabolism in patients with metabolic syndrome in dependence of liver fibrosis intensity. Materials and methods. We investigated 129 patients with obesity and metabolic syndrome aged 18-59 years old (average age 44 (38+47) years), who underwent elastometry and fibrosis intensity was estimated in dependence of accompanying metabolic disorders (lipid and glucose). Results. Glucose metabolic disorders are accompanied by non-alcohol fatty liver disease in 100%, and elastometric fibrosis features are present in 61% of these patients. If liver fibrosis is present, independently of its intensity, in patients without glucose metabolism disturbances insulin resistance is twofold more often (HOMA index >2.7), while there was no significant correlation of fibrosis with atherogenic profile changes. Conclusion. According to elastometry lipid and glucose disorders are not associated with liver fibrosis intensity.