associations between mobility, cognition, and brain structure in healthy older adults
Clicks: 190
ID: 232798
2017
Mobility limitations lead to a cascade of adverse events in old age, yet the neural and cognitive correlates of mobility performance in older adults remain poorly understood. In a sample of 387 adults (mean age 69.0 ± 5.1 years), we tested the relationship between mobility measures, cognitive assessments, and MRI markers of brain structure. Mobility was assessed in 2007–2009, using gait, balance and chair-stands tests. In 2012–2015, cognitive testing assessed executive function, memory and processing-speed; gray matter volumes (GMV) were examined using voxel-based morphometry, and white matter microstructure was assessed using tract-based spatial statistics of fractional anisotropy, axial diffusivity (AD), and radial diffusivity (RD). All mobility measures were positively associated with processing-speed. Faster walking speed was also correlated with higher executive function, while memory was not associated with any mobility measure. Increased GMV within the cerebellum, basal ganglia, post-central gyrus, and superior parietal lobe was associated with better mobility. In addition, better performance on the chair-stands test was correlated with decreased RD and AD. Overall, our results indicate that, even in non-clinical populations, mobility measures can be sensitive to sub-clinical variance in cognition and brain structures.
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| Authors | ;Naiara Demnitz;Naiara Demnitz;Enikő Zsoldos;Abda Mahmood;Clare E. Mackay;Mika Kivimäki;Archana Singh-Manoux;Helen Dawes;Heidi Johansen-Berg;Klaus P. Ebmeier;Claire E. Sexton |
| Journal | Frontiers in chemistry |
| Year | 2017 |
| DOI | 10.3389/fnagi.2017.00155 |
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