aspectos clínicos e sorológicos de 47 pacientes com paracoccidioidomicose tratados pela anfotericina b clinical and serologic features of 47 patients with paracoccidioidomycosis treated by amphotericin b

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ID: 232237
1984
In the present study, clinic and serologic aspects of 47 paracoccidioidomycosis patients were reviewed. The clinic-radiologie-laboratorial data of each patient were obtained from the medical chart before, during and after therapy with Amphotericin B. The age of the patients ranged between 13 to 50 years; the ratio male: female was 10:1. The most frequently associated diseases were alcoholism and tabagism; tuberculosis was present in 14.2% of the cases. Most patients came from Botucatu of adjacent towns (central area of the State of São Paulo). Cough with sputum production, dyspnea and anorexia were the most frequent clinic manifestations. All 47 patients, but 5 presented pulmonary involvement which showed the radiologic pattern of interstitial exudate nodular type and fibrocicatritial lesions in 85.7%. There was associated emphysema in 37.7% of the patients. Blood urea, creatinin and kaliemia increased during therapy with Amphotericin B. Clinic-laboratorial follow-up showed electrocardiographic changes in 13, hypertension in 9 and hyperreactivity in Thorn test in 1 patient. Complement fixation was the best serologic test for monitoring patients with paracoccidioidomycosis. Incomplete dosage of Amphotericin B led to therapeutic ineffectivenes.
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Authors ;Evanil Pires de Campos;José Carlos Sartori;Maria Lúcia Hetch;Marcello Fabiano de Franco
Journal 2017 12th international conference for internet technology and secured transactions, icitst 2017
Year 1984
DOI DOI not found
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651984000400005
Keywords
tropical medicine arctic medicine

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