short-term hemodynamic effects of apelin in patients with pulmonary arterial hypertension
Clicks: 134
ID: 231363
2018
Summary: Apelin agonism causes systemic vasodilatation and increased cardiac contractility in humans, and improves pulmonary arterial hypertension (PAH) in animal models. Here, the authors examined the short-term pulmonary hemodynamic effects of systemic apelin infusion in patients with PAH. In a double-blind randomized crossover study, 19 patients with PAH received intravenous (Pyr1)apelin-13 and matched saline placebo during invasive right heart catheterization. (Pyr1)apelin-13 infusion caused a reduction in pulmonary vascular resistance and increased cardiac output. This effect was accentuated in the subgroup of patients receiving concomitant phosphodiesterase type 5 inhibition. Apelin agonism is a novel potential therapeutic target for PAH. (Effects of Apelin on the Lung Circulation in Pulmonary Hypertension; NCT01457170) Key Words: apelin, APJ, human, pulmonary arterial hypertension
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md2018jacc:short-term
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| Authors | ;Lauren Brash, MD;Gareth D. Barnes, MD;Melanie J. Brewis, MD;A. Colin Church, MD;Simon J. Gibbs, MD;Luke S.G.E. Howard, MD;Geeshath Jayasekera, MBChB;Martin K. Johnson, MD;Neil McGlinchey, MBChB;Joelle Onorato, PhD;Joanne Simpson, MD;Colin Stirrat, MD;Stephen Thomson, MBChB;Geoffrey Watson, MD;Martin R. Wilkins, MD;Carrie Xu, MS;David J. Welsh, PhD;David E. Newby, MD;Andrew J. Peacock, MD |
| Journal | journal of nuclear materials |
| Year | 2018 |
| DOI | DOI not found |
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