the prevalence of chronic kidney disease in patients with acute coronary syndrome

Abstract

Background: Chronic kidney disease (CKD) is a worldwide public health problem. Glomerular filtration rate (GFR) is often estimated from serum creatinine. Recently several formulas for estimation of GFR have been developed. The most widely used are the Modification of Diet in Renal Disease (MDRD) Study equation and Cockcroft-Gault equation (C & G). The prevalence of CKD is rising. The patients with CKD are at increased risk of cardiovascular disease.

Patients and methods: In our study 449 patients (308 men and 141 women) with acute coronary syndrome and percutaneous coronary intervention were included. The average age was 63 years (SD ± 11.9). We collected blood samples for measuring serum concentrations of creatinine. The GFR was estimated using the MDRD Study equation and C & G equation.

Results In our study women were statistically significantly older than men. 369 patients (82 %) had an acute myocardial infarction. The prevalence of CKD was 26.3 % when GFR was estimated by MDRD Study equation and 25.8 % when GFR was estimated by C & G equation. A greater prevalence of CKD was found in women and in patients older than 65 years old. Stages of CKD correlated with age and gender of the patients, with previously known ishemic heart disease and with diffuse coronary artery disease.

Conclusions: In our study the prevalence of CKD in patients with acute coronary syndrome was high. CKD was an independent predictor for development of diffuse coronary artery disease.