regulation of extracellular matrix in patients with q-wave myocardial infarction after thrombolytic therapy

Abstract

Aims. In order to study the levels of matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, intracardiac hemodynamics, frequency of acute cardiac aneurysm development in patients with Q-wave myocardial infarction after thrombolysis, 74 patients were examined. Methods and results. All participants underwent clinical and laboratory examination, echocardiography, determination of serum levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1. Conclusion. Patients, who got thrombolysis in 6 to 12 hours period, had excessive activation of the proteolysis system on the background of relative defi cit of tissue inhibitor of metalloproteinase-1, the prevalence of dilatation and restrictive diastolic dysfunction, cardiac aneurysm was detected frequently and thrombogenic potential was higher.