constituintes químicos de parmotrema lichexanthonicum eliasaro & adler: isolamento, modificações estruturais e avaliação das atividades antibiótica e citotóxica chemical constituents of parmotrema lichexanthonicum eliasaro & adler: isolation, structure modification and evaluation of antibiotic and cytotoxic activities

Clicks: 83
ID: 212221
2009
From the lichen Parmotrema lichexantonicum were isolated the depsidone salazinic acid, the xanthone lichexanthone, and the depside atranorin. The two major compounds, salazinic acid and lichexanthone, were selected for structure modifications. Salazinic acid afforded O-alkyl salazinic acids, some of them potentially cytotoxic against tumor cell lines (HCT-8, SF-295 and MDA/ MB - 435). From lichexanthone were obtained norlichexanthone, 3-O-methylnorlichexanthone, 3-O-methyl-6-O-prenylnorlichexanthone, 3,6-di-O-prenyl-norlichexanthone, 3,6-bis[(3,3-dimethyloxyran-2-il)methoxy]-1-hydroxy-8-methyl-9H-xanten-9-one and 3,6-bis[3-(dimethylamine)propoxy]-1-hydroxy-8-methyl-9H-xanten-9-one. The last compound was the most active against S. aureus.
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Authors ;Ana C. Micheletti;Adilson Beatriz;Dênis Pires de Lima;Neli K. Honda;Cláudia do Ó Pessoa;Manoel Odorico de Moraes;Letícia Veras Lotufo;Hemerson Iury Ferreira Magalhães;Nádia C. P. Carvalho
Journal greece and rome
Year 2009
DOI 10.1590/S0100-40422009000100003
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000100003
Keywords
lichenschemistry

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