Dehydrative Transformation of Spirooxindoles to Pyrido[2,3-]indoles via POCl.
Clicks: 200
ID: 20728
2019
A two-step one-pot efficient synthesis of pyrido[2,3-]indoles via reaction between isatin, α-amino acid, and dipolarophile has been developed. The initial 1,3-dipolar cycloaddition between the reactants that is performed in the presence of either CuI or methanol results in spirooxindoles that undergo POCl-mediated intramolecular dehydrative transformation to afford the title compounds.
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kolle2019dehydrativeacs
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| Authors | Kolle, Shivalinga;Barak, Dinesh S;Ghosh, Aritra;Jaiswal, Vandana;Kant, Ruchir;Batra, Sanjay; |
| Journal | ACS omega |
| Year | 2019 |
| DOI | 10.1021/acsomega.9b00396 |
| URL | |
| Keywords | Keywords not found |
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