systems approach to the study of brain damage in the very preterm newborn

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2015
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Background: A systems approach to the study of brain damage in very preterm newborns has been lackingMethods: In this perspective piece, we offer encephalopathy of prematurity as an example of the complexity and interrelatedness of brain-damaging molecular processes that can be initiated inflammatory phenomena. Results: Using three transcription factors, nuclear factor-kappa B (NF-κB), Notch-1, and nuclear factor erythroid 2 related factor 2 (NRF2), we show the inter-connectedness of signaling pathways activated by some antecedents of encephalopathy of prematurity. Conclusions: We hope that as biomarkers of exposures and processes leading to brain damage in the most immature newborns become more readily available, those who apply a systems approach to the study of neuroscience can be persuaded to study the pathogenesis of brain disorders in the very preterm newborn.
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eleviton2015frontierssystems Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Alan eLeviton;Pierre eGressens;Olaf eWolkenhauer;Olaf eDammann
Journal Vacuum
Year 2015
DOI 10.3389/fnsys.2015.00058
URL
http://journal.frontiersin.org/Journal/10.3389/fnsys.2015.00058/full
Keywords
inflammation systems biology epigenetic prematurity brain neuropsychiatry biological psychiatry

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