the promise and challenge of induced pluripotent stem cells for cardiovascular applications

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ID: 193425
2016
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Abstract
The recent discovery of human-induced pluripotent stem cells (iPSC) has revolutionized the field of stem cells. iPSC have demonstrated that biological development is not an irreversible process and that mature adult somatic cells can be induced to become pluripotent. This breakthrough is projected to advance our current understanding of many disease processes and revolutionize the approach to effective therapeutics. Despite the great promise of iPSC, many translational challenges still remain. The authors review the basic concept of induction of pluripotency as a novel approach to understand cardiac regeneration, cardiovascular disease modeling, and drug discovery. They critically reflect on the current results of pre-clinical and clinical studies using iPSC for these applications with appropriate emphasis on the challenges facing clinical translation.
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phd2016jacc:the Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Amr A. Youssef, MD, PhD;Elsie Gyang Ross, MD, MSc;Roberto Bolli, MD;Carl J. Pepine, MD;Nicholas J. Leeper, MD;Phillip C. Yang, MD
Journal journal of nuclear materials
Year 2016
DOI 10.1016/j.jacbts.2016.06.010
URL
http://www.sciencedirect.com/science/article/pii/S2452302X16301103
Keywords
cardiomyopathy calcium drug discovery disease modeling cardiac regeneration mitochondriadiseases of the circulatory (cardiovascular) system

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