pharmacological modulation of anti-tumor immunity induced by oncolytic viruses

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ID: 191243
2014
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Abstract
Oncolytic viruses kill cancer cells by direct lysis but also generate a significant anti-tumor immune response that allows for prolonged cancer control and in some cases cures. How to best stimulate this effect is a subject of intense investigation in the oncolytic virus field. While pharmacological manipulation of the cellular innate antiviral immune response has been shown by several groups to improve viral oncolysis and spread, it is increasingly clear that pharmacological agents can also impact the anti-tumor immune response generated by oncolytic viruses and related tumor vaccination strategies. This review covers recent progress in using pharmacological agents to improve the activity of oncolytic viruses and their ability to generate robust anti-tumor immune responses.
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forbes2014frontierspharmacological Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Nicole E. Forbes;Nicole E. Forbes;Ramya eKrishnan;Ramya eKrishnan;Jean-Simon eDiallo;Jean-Simon eDiallo
Journal international journal of heat and technology
Year 2014
DOI 10.3389/fonc.2014.00191
URL
http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00191/full
Keywords
Cancer Chemotherapy combination therapy Oncology including cancer and carcinogens tumors

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