isosakuranetin-5-o-rutinoside: a new flavanone with antidepressant activity isolated from salvia elegans vahl.

Clicks: 195
ID: 188898
2013
Ursolic acid (1) and a new flavanone, 5-O-(6-rhamnosylglucoside)-7-hydroxy-4'-methoxyflavanone (2), were isolated from the leaves of Salvia elegans Vahl. These natural products displayed antidepressant activity in mice as determined by means of a forced swimming test (FST) evaluation. Structural elucidation was carried out by chemical derivatization (acetylation) and spectroscopic analyses, such as 1H- and 13C-NMR and two-dimensional (2-D) COSY, heteronuclear multiple quantum coherence (HMQC), and heteronuclear multiple-bond correlation (HMBC) spectroscopy experiments.
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Authors ;Manáses González-Cortazar;Ana María Maldonado-Abarca;Enrique Jiménez-Ferrer;Silvia Marquina;Elsa Ventura-Zapata;Alejandro Zamilpa;Jaime Tortoriello;Maribel Herrera-Ruiz
Journal Journal of ethnopharmacology
Year 2013
DOI 10.3390/molecules181113260
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