effect of perindopril on the myocardial energy consumption in patients with heart failure after myocardial infarction
Clicks: 256
ID: 181466
2017
Objective: To explore the clinical efficacy of perinodopril in the treatment of heart failure
in patients after myocardial infarction and effect on the myocardial energy consumption.
Methods: A total of 87 patients with heart failure after myocardial infarction who were
admitted in our hospital from August, 2014 to October, 2015 were included in the study
and divided into the routine dose group (n=43, perinodopril 4 mg/d) and high dose group
(n=44, perinodopril 8 mg/d) according to the long-term oral dose. All the patients were given
perinodopril, continuously for 6 months. The changes of blood pressure and serum biochemical
indicators before and after treatment in the two groups were compared. The changes of cardiac
function indicators and myocardial energy consumption indicators before and after treatment
in the two groups were compared. 6MWT 6 months and 1 year after treatment in the two
groups was calculated. Results: The plasma BNP and H-FABP levels, LVEDD, LVESD,
MEE, and cESS after treatment in the two groups were significantly reduced when compared
with before treatment, and those in the high dose group were significantly lower than those
in the low dose group. LVEF and FS after treatment in the two groups were significantly
increased, and those in the high dose group were significantly greater than those in the routine
dose group. The seurm potassium level after treatment in the high dose group was significantly
elevated when compared with before treatment, but was not significantly different from that
in the routine dose group. SBP, DBP, and Scr levels after treatment in the two groups were not
significantly changed. 6MWT 6 months and 1 year after treatment in the high dose group was
significantly greater than that in the routine dose group. Conclusions: Perinodopril in a high
dose can significantly reduce the plasma BNP and H-FABP levels in patients with heart failure
after myocardial infarction, inhibit the ventricular remodeling, promote the recovery of systolic
function, reduce the myocardial energy consumption, and will not affect the blood pressure,
serum potassium, and renal function, with efficacy significantly superior to that in a low dose;
moreover, it has a certain safety.
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| Authors | ;Da-Peng Li;Dang-Hui Sun;Lin Wei;Xi-Ying Yu;Shi-Jin Na |
| Journal | journal of communications |
| Year | 2017 |
| DOI | DOI not found |
| URL | |
| Keywords |
ophthalmology
cytokines
myocardial infarction
acute myocardial infarction
heart failure
inflammatory response
hyperbaric oxygen
inflammatory factor
cardiac function
irbesartan
inflammatory cytokine
acs
rosuvastatin
maintenance hemodialysis
postoperative analgesia
glass
Ceramics
inflammatory cytokinesmedicine
cardiac functionmedicine
polyvinylpyrrolidoneclay industries
oxidative stressmedicine
neuroendocrine hormone
|
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