pml surfs into hippo tumor suppressor pathway

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ID: 175053
2013
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Abstract
Growth arrest, inhibition of cell proliferation, apoptosis, senescence and differentiation are the most characterized effects of a given tumor suppressor response. It is becoming increasingly clear that tumor suppression results from the integrated and synergistic activities of different pathways. This implies that tumor suppression includes linear, as well as lateral, crosstalk signaling. The latter may happen through the concomitant involvement of common nodal proteins. Here, we discuss the role of Promyelocytic leukemia protein (PML) in functional cross-talks with the HIPPO and the p53 family tumor suppressor pathways. PML, in addition to its own anti-tumor activity, contributes to the assembly of an integrated and superior network that may be necessary for the maximization of the tumor suppressor response to diverse oncogenic insults.
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Authors ;Sabrina eStrano;Francesca eFausti;Silvia eDi Agostino;Marius eSudol;Marius eSudol;Giovanni eBlandino
Journal international journal of heat and technology
Year 2013
DOI 10.3389/fonc.2013.00036
URL
http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00036/full
Keywords
pathway transcription interaction signaling Oncology including cancer and carcinogens tumors

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