development of curcumin liposome formulations using polyol dilution method

Abstract

This study was aimed to formulate curcumin liposomes (CLs) by using polyol dilution method which is advantageous for no residue of organic solvent. CLs were the mixture of hydrogenated phosphatidylcholine (PC) and cholesterol (CH) at the molar ratio of 9:1. Propylene glycol (PG), glycerin, and polyethylene glycol 400 (PEG-400) were used as polyol solvent. Extrusion was applied after the suspension formed. The amount of polyol and curcumin and preparing temperature were investigated. The obtained suspensions were observed for appearance, size, size distribution, zeta potential, morphology, and percentage of entrapment. The results showed that type and amount of polyol had an impact on both liposomal size and the amount of entrapped curcumin, while preparing temperature was also an important factor. However, the solubility of lipids and drug in a given polyol should be considered because of loading efficiency in the formulation.