astrocytosis in parkinsonism: considering tripartite striatal synapses in physiopathology?
Clicks: 199
ID: 174190
2014
The current concept of basal ganglia organization and function in physiological and pathophysiological conditions excludes the most numerous cells in the brain, i.e. the astrocytes, present with a ratio of 10:1 neuron. Their role in neurodegenerative condition such as Parkinson’s disease (PD) remains to be elucidated. Before embarking into physiological investigations of the yet-to-be-identified tripartite synapses in the basal ganglia in general and the striatum in particular, we therefore characterized anatomically the PD-related modifications in astrocytic morphology, the changes in astrocytic network connections and the consequences on the spatial relationship between astrocytic processes and asymmetric synapses in normal and PD-like conditions in experimental and human PD. Our results unravel a dramatic regulation of striatal astrocytosis supporting the hypothesis of a key role in (dys)regulating corticostriatal transmission. Astrocytes and their various properties might thus represent a therapeutic target in PD.
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echarron2014frontiersastrocytosis
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| Authors | ;Giselle eCharron;Evelyne eDoudnikoff;Marie-Helene eCanron;Qin eLi;Celine eVega;sebastien eMarais;Jerome eBaufreton;Anne eVital;Stéphane H Oliet;Erwan eBezard |
| Journal | Frontiers in chemistry |
| Year | 2014 |
| DOI | 10.3389/fnagi.2014.00258 |
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