A novel thermo-responsive multiblock architecture composed of a sequential peptide and an amino acid-derived vinyl polymer: toward protein-mimicking single-chain folding.
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2019
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Abstract
A novel multiblock architecture composed of an alternating β-sheet forming oligopeptide and a thermo-responsive glycine-derived vinyl polymer was synthesized. The polymer exhibited lower critical solution temperature (LCST) behavior in water, unlike the behavior of a glycine-derived homopolymer, and formed nanoparticles through protein-mimicking folding driven by thermal cycle-induced β-sheet formation.Reference Key |
nishimura2019achemical
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Authors | Nishimura, Shin-Nosuke;Higashi, Nobuyuki;Koga, Tomoyuki; |
Journal | Chemical communications (Cambridge, England) |
Year | 2019 |
DOI | 10.1039/c8cc09051c |
URL | |
Keywords | Keywords not found |
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