promising biocompatible hydrogels of crosslinked polyelectrolytes for biomedical applications
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2017
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Abstract
For the development of intelligent implant systems hydrogels (HG) from crosslinked ionic liquids feature a high potential to be utilised as a drug depot. Biocompatibility of the HGs is one key prerequisite for biomedical applications. HGs were polymerised from a variety of different ionic monomers based on methacrylate, methacrylamide, styrene or vinyl imidazolium derivatives in aqueous solution. N,N'-methylenebisacrylamide was used as crosslinker. CellQuanti-Blue™ Cell Viability Assay Kit was implemented to proof viability of L929 mouse fibroblasts. The predominant part of the HG eluates generated only a marginal reduction of less than 15% cell viability at 100% eluate concentration. This underlines the excellent suitability of these HGs for biomedical applications and revealed some promising candidates for the development of drug depots for implants.| Reference Key |
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| Authors | ;Brietzke Andreas;von der Ehe Christian;Illner Sabine;Matschegewski Claudia;Grabow Niels;Kragl Udo |
| Journal | materials science and engineering c |
| Year | 2017 |
| DOI | 10.1515/cdbme-2017-0147 |
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