design and synthesis of new cholesterol-conjugated 5-fluorouracil: a novel potential delivery system for cancer treatment
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2014
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Abstract
Cholesterol-conjugated 5-fluorouracil prodrugs were designed to be carried in vivo via low density lipoproteins (LDL) and subsequently undergo LDL-receptor-mediated internalisation into cancer cells. In vivo anti-cancer evaluation was performed using 5-fluorouracil-cholesterol conjugate in a mouse model. The obtained prodrugs were more potent than 5-fluorouracil control drug at the same 5-fluorouracil content (3 mg·kg−1).| Reference Key |
radwan2014moleculesdesign
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| Authors | ;Awwad A. Radwan;Fares K. Alanazi |
| Journal | Journal of ethnopharmacology |
| Year | 2014 |
| DOI | 10.3390/molecules190913177 |
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