roles of elevated intravitreal il-1β and il-10 levels in proliferative diabetic retinopathy

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ID: 160552
2014
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Abstract
Purpose: To determine the roles of interleukin (IL)-1β and IL-10 in the vitreous of proliferative diabetic retinopathy (PDR). Materials and Methods: Vitreous samples were obtained from 26 eyes of 26 patients with PDR and from eight eyes of eight cases without PDR. The IL-1β and IL-10 concentration in the vitreous was measured by using an enzyme-linked immunosorbent assay (ELISA). Results: Levels of IL-1β and IL-10 in vitreous were higher in PDR patients compared with control group. And there was significantly negative correlation between IL-1β and IL-10 in control group (r = −0.795; P = 0.032), whereas there was no significant correlation in PDR group (r = 0.176; P = 0.391). Conclusion: Levels of IL-1β and IL-10 were upregulated in vitreous of PDR patients, and these two cytokines play roles in regulating the development and progression of PDR.
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Authors ;Chunjie Mao;Hua Yan
Journal Bioinformatics
Year 2014
DOI 10.4103/0301-4738.136220
URL
http://www.ijo.in/article.asp?issn=0301-4738;year=2014;volume=62;issue=6;spage=699;epage=701;aulast=Mao
Keywords
Diabetic retinopathy immunology agreement intraocular pressure power interleukin-1β axial length interleukin-10 enzyme-linked immunosorbent assay accommodation hypertensive retinopathy lens twin pregnancy amplitude of accommodation

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