brain structure across the lifespan: the influence of stress and mood
Clicks: 220
ID: 158950
2014
Normal brain aging is an inevitable and heterogeneous process characterized by a selective pattern of structural changes. Such heterogeneity arises as a consequence of cumulative effects over the lifespan, including stress and mood effects, which drive different micro- and macro-structural alterations in the brain. Investigating these differences in healthy age-related changes is a major challenge for the comprehension of the cognitive status. Herein we addressed the impact of normal aging, stress, mood and their interplay in the brain gray and white matter structure. We showed the critical impact of age in the white matter volume and how stress and mood influence brain volumetry across the lifespan. Moreover, we found a more profound effect of the interaction of aging/stress/mood on structures located in the left hemisphere. These findings help to clarify some divergent results associated with the aging decline and to enlighten the association between abnormal volumetric alterations and several states that may lead to psychiatric disorders.
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soares2014frontiersbrain
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| Authors | ;Jose Miguel Soares;Jose Miguel Soares;Jose Miguel Soares;Paulo César Gonçalves Marques;Paulo César Gonçalves Marques;Paulo César Gonçalves Marques;Ricardo eMagalhães;Ricardo eMagalhães;Ricardo eMagalhães;Nadine Correia Santos;Nadine Correia Santos;Nadine Correia Santos;Nuno eSousa;Nuno eSousa;Nuno eSousa |
| Journal | Frontiers in chemistry |
| Year | 2014 |
| DOI | 10.3389/fnagi.2014.00330 |
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