biologically active echinulin-related indolediketopiperazines from the marine sediment-derived fungus aspergillus niveoglaucus
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ID: 155900
2019
Seven known echinulin-related indolediketopiperazine alkaloids (1−7) were isolated from the Vietnamese sediment-derived fungus Aspergillus niveoglaucus. Using chiral HPLC, the enantiomers of cryptoechinuline B (1) were isolated as individual compounds for the first time. (+)-Cryptoechinuline B (1a) exhibited neuroprotective activity in 6-OHDA-, paraquat-, and rotenone-induced in vitro models of Parkinson’s disease. (−)-Cryptoechinuline B (1b) and neoechinulin C (5) protected the neuronal cells against paraquat-induced damage in a Parkinson’s disease model. Neoechinulin B (4) exhibited cytoprotective activity in a rotenone-induced model, and neoechinulin (7) showed activity in the 6-OHDA-induced model.
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smetanina2019moleculesbiologically
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| Authors | ;Olga F. Smetanina;Anton N. Yurchenko;Elena V. Girich (Ivanets);Phan Thi Hoai Trinh;Alexander S. Antonov;Sergey A. Dyshlovoy;Gunhild von Amsberg;Natalya Y. Kim;Ekaterina A. Chingizova;Evgeny A. Pislyagin;Ekaterina S. Menchinskaya;Ekaterina A. Yurchenko;Tran Thi Thanh Van;Shamil S. Afiyatullov |
| Journal | Journal of ethnopharmacology |
| Year | 2019 |
| DOI | 10.3390/molecules25010061 |
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