controlled release of retinol in cationic co-polymeric nanoparticles for topical application

Retinol is a compound used in many skin care formulations to act against skin conditions like acne, wrinkles, psoriasis, and ichthyosis. While retinol is used as an active ingredient, its efficacy is limited by an extreme sensitivity to light and temperature. Retinol can also generate toxicity at high concentrations. Microencapsulation is an alternative method to help overcome these issues. In this study, we develop a new encapsulation of retinol by solvent evaporation using a cationic polymer. We show that our particles have a narrow size distribution (350 nm), can encapsulate retinol with high efficiency, and protect it from oxidation for at least eight weeks. Finally, to demonstrate that the release of retinol from the particles can be controlled, we performed a kinetic study and showed that the particle releases the drug during 18 h.