apoptosis induced by the tibetan herbal remedy padma 28 in the t cell-derived lymphocytic leukaemia cell line cem-c7h2

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2005
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Abstract

Abstract

The Tibetan herbal remedy PADMA 28 revealed promising results to support treatment of atherosclerosis, Charot syndrome (intermittent claudication), chronic active hepatitis and infection of the respiratory tract. The remedy was confirmed to be closely linked with anti- and pro-oxidative properties in vitro. In this study, apoptogenic and survival effects of PADMA 28 were investigated in the T cell-derived lymphocytic leukaemia cell line CEM-C7H2.

PADMA 28 led to a concentration-dependent inhibition of cell proliferation accompanied by the accumulation of CEM-C7H2 cells in subG1 phase, fragmentation of poly (ADP-ribose) polymerase (PARP) and nuclear body formation. Treatment with PADMA 28 rescued to some extent cells over-expressing Bcl-2 from apoptosis. This finding suggests that the mechanism of action of PADMA 28 may be via interference with Bcl-2 triggered survival pathways.

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marcel2005journalapoptosis Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Jenny Marcel;Schwaiger Wolfgang;Bernhard David;Wrulich Oliver A;Cosaceanu Daria;Fuchs Dietmar;Ueberall Florian
Journal italian journal of mycology
Year 2005
DOI 10.1186/1477-3163-4-15
URL
http://www.carcinogenesis.com/content/4/1/15
Keywords
apoptosis bcl-2 Oncology including cancer and carcinogens tumors

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