métodos de obtenção, reatividade e importância biológica de 4-tiazolidinonas preparation methods, reactivity and biological importance of 4-thiazolidinones

Clicks: 133
ID: 146719
2008
Molecules containing the 4-thiazolidinone ring are known to possess a wide range of biological properties including antimicrobial and anti-inflammatory activities among others. These compounds can be synthesized by cyclization reactions involving alpha-haloacetic acid or alpha-mercaptoacetic acid and employed in several chemoselective reactions. Comprehensive reviews have been written on 4-thiazolidinones in 1961 by Brown and in 1980 by Singh et al. In the recent literature, some new synthesis methods for 4-thiazolidinone derivatives and several reactions have been reported. These advances warrant to review the chemical and biological properties of compounds with this important heterocycle employed in synthetic organic chemistry and medicinal chemistry.
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Authors ;André P. Liesen;Thiago M. de Aquino;Alexandre J. S. Góes;José G. de Lima;Antônio R. de Faria;Antonio J. Alves
Journal greece and rome
Year 2008
DOI 10.1590/S0100-40422008000200033
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000200033
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