crl ubiquitin ligases and dna damage response

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ID: 145998
2012
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Abstract
Cullin/RING ubiquitin ligases (CRL) comprise the largest subfamily of ubiquitin ligases and are involved in various biological processes. One of the main functions of CRLs is to regulate DNA damage response, a fundamental signaling cascade to maintain genome integrity. In this review, we will discuss the regulation of CRL ubiquitin ligases and their roles in control of DNA damage response.
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ejin2012frontierscrl Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Jianping eJin;Ju-Mei eLi
Journal international journal of heat and technology
Year 2012
DOI 10.3389/fonc.2012.00029
URL
http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00029/full
Keywords
dna damage cyclin d1 protein degradation cdc25a Oncology including cancer and carcinogens tumors

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