leptin therapy, insulin sensitivity, and glucose homeostasis

Clicks: 243
ID: 138958
2012
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Abstract
Glucose homeostasis is closely regulated not only by insulin, but also by leptin. Both hormones act centrally, regulating food intake and adiposity in humans. Leptin has several effects on the glucose-insulin homeostasis, some of which are independent of body weight and adiposity. Those effects of leptin are determined centrally in the hypothalamus and peripherally in the pancreas, muscles and liver. Leptin has beneficial effects on the glucose-insulin metabolism, by decreasing glycemia, insulinemia and insulin resistance. The understanding of the effects of leptin on the glucose-insulin homeostasis will lead to the development of leptin-based therapies against diabetes and other insulin resistance syndromes. In these review, we summarize the interactions between leptin and insulin, and their effects on the glucose metabolism.
Reference Key
paz-filho2012indianleptin Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Gilberto Paz-Filho;Claudio Mastronardi;Ma-Li Wong;Julio Licinio
Journal journal of physical chemistry a
Year 2012
DOI 10.4103/2230-8210.105571
URL
http://www.ijem.in/article.asp?issn=2230-8210;year=2012;volume=16;issue=9;spage=549;epage=555;aulast=Paz-Filho
Keywords
Diabetes insulin resistance insulin glucose Gastroenterology clinical endocrinologydiseases of the digestive system

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