micrornas signatures, bioinformatics analysis of mirnas, mirna mimics and antagonists, and mirna therapeutics in osteosarcoma
Clicks: 462
ID: 135729
2020
Abstract MicroRNAs (miRNAs) involved in key signaling pathways and aggressive phenotypes of osteosarcoma (OS) was discussed, including PI3K/AKT/MTOR, MTOR AND RAF-1 signaling, tumor suppressor P53- linked miRNAs, NOTCH- related miRNAs, miRNA -15/16 cluster, apoptosis related miRNAs, invasion-metastasis-related miRNAs, and 14Q32-associated miRNAs cluster. Herrin, we discussed insights into the targeted therapies including miRNAs (i.e., tumor-suppressive miRNAs and oncomiRNAs). Using bioinformatics tools, the interaction network of all OS-associated miRNAs and their targets was also depicted.
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otoukesh2020cancermicrornas
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| Authors | ;Babak Otoukesh;Mehdi Abbasi;Habib-o-Lah Gorgani;Hossein Farahini;Mehdi Moghtadaei;Bahram Boddouhi;Peyman Kaghazian;Shayan Hosseinzadeh;Atefe Alaee |
| Journal | management and economics review |
| Year | 2020 |
| DOI | 10.1186/s12935-020-01342-4 |
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