Genome Sequencing in Open Microfabricated High Density Picoliter Reactors
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ID: 120700
2005
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We describe a scalable, highly parallel sequencing system with raw throughput significantly greater than that of state-of-the-art capillary electrophoresis instruments. The apparatus uses a novel 60×60 mm[2] fibreoptic slide containing 1,600,000 ...
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| Authors | Marcel Margulies, Michael Egholm, William E. Altman, Said Attiya, Joel S. Bader, Lisa A. Bemben, Jan Berka, Michael S. Braverman, Yi-Ju Chen, Zhoutao Chen, Scott B. Dewell, Lei Du, Joseph M. Fierro, Xavier V. Gomes, Brian C. Goodwin, Wen He, Scott Helgesen, Chun He Ho, Gerard P. Irzyk, Szilveszter C. Jando, Maria L.I. Alenquer, Thomas P. Jarvie, Kshama B. Jirage, Jong-Bum Kim, James R. Knight, Janna R. Lanza, John H. Leamon, Steven M. Lefkowitz, Ming Lei, Jing Li, Kenton L. Lohman, Hong Lu, Vinod B. Makhijani, Keith E. McDade, Michael P. McKenna, Eugene W. Myers, Elizabeth Nickerson, John R. Nobile, Ramona Plant, Bernard P. Puc, Michael T. Ronan, George T. Roth, Gary J. Sarkis, Jan Fredrik Simons, John W. Simpson, Maithreyan Srinivasan, Karrie R. Tartaro, Alexander Tomasz, Kari A. Vogt, Greg A. Volkmer, Shally H. Wang, Yong Wang, Michael P. Weiner, Pengguang Yu, Richard F. Begley, Jonathan M. Rothberg;Marcel Margulies;Michael Egholm;William E. Altman;Said Attiya;Joel S. Bader;Lisa A. Bemben;Jan Berka;Michael S. Braverman;Yi-Ju Chen;Zhoutao Chen;Scott B. Dewell;Lei Du;Joseph M. Fierro;Xavier V. Gomes;Brian C. Goodwin;Wen He;Scott Helgesen;Chun He Ho;Gerard P. Irzyk;Szilveszter C. Jando;Maria L.I. Alenquer;Thomas P. Jarvie;Kshama B. Jirage;Jong-Bum Kim;James R. Knight;Janna R. Lanza;John H. Leamon;Steven M. Lefkowitz;Ming Lei;Jing Li;Kenton L. Lohman;Hong Lu;Vinod B. Makhijani;Keith E. McDade;Michael P. McKenna;Eugene W. Myers;Elizabeth Nickerson;John R. Nobile;Ramona Plant;Bernard P. Puc;Michael T. Ronan;George T. Roth;Gary J. Sarkis;Jan Fredrik Simons;John W. Simpson;Maithreyan Srinivasan;Karrie R. Tartaro;Alexander Tomasz;Kari A. Vogt;Greg A. Volkmer;Shally H. Wang;Yong Wang;Michael P. Weiner;Pengguang Yu;Richard F. Begley;Jonathan M. Rothberg; |
| Journal | Nature |
| Year | 2005 |
| DOI | 10.1038/nature03959 |
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