The PI3K Pathway in Human Disease

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2017
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Abstract
Phosphoinositide 3-kinase (PI3K) activity is stimulated by diverse oncogenes and growth factor receptors, and elevated PI3K signaling is considered a hallmark of cancer. Many PI3K pathway-targeted therapies have been tested in oncology trials, resulting in regulatory approval of one isoform-selectiv ā€¦
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Authors Fruman DA;Chiu H;Hopkins BD;Bagrodia S;Cantley LC;Abraham RT;;
Journal Cell
Year 2017
DOI DOI not found
URL
https://www.ncbi.nlm.nih.gov/pubmed/28802037
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE review animals humans pubmed abstract nih national institutes of health national library of medicine signal transduction* neoplasms / drug therapy neoplasms / pathology neoplasms / metabolism pmid:28802037 pmc5726441 doi:10.1016/j.cell.2017.07.029 david a fruman honyin chiu robert t abraham cell physiological phenomena immune system / metabolism phosphatidylinositol 3-kinases / metabolism*

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