Novel 1,4-naphthoquinone derivatives induce apoptosis via ROS-mediated p38/MAPK, Akt and STAT3 signaling in human hepatoma Hep3B cells

Clicks: 323
ID: 119377
2018
1,4-Naphthoquinone and its derivatives have shown some efficacy as therapeutic compounds for cancer and inflammation, though their clinical application is limited by their side-effects. To reduce the toxicity of these compounds and optimize their effects, we synthesized two 1,4-naphthoquinone deriva …
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Authors Liu C;Shen GN;Luo YH;Piao XJ;Jiang XY;Meng LQ;Wang Y;Zhang Y;Wang JR;Wang H;Xu WT;Li JQ;Liu Y;Wu YQ;Sun HN;Han YH;Jin MH;Cui YD;Fang NZ;Jin CH;;
Journal the international journal of biochemistry & cell biology
Year 2018
DOI DOI not found
URL
https://www.pubmed.gov/29326072/
Keywords
Tumor National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't cell line carcinoma proto-oncogene proteins c-akt / metabolism* apoptosis / drug effects* reactive oxygen species / metabolism* hepatocellular / pathology liver neoplasms / pathology cheng-hao jin naphthoquinones / pharmacology* gui-nan shen pmid:29326072 doi:10.1016/j.biocel.2018.01.004 chang liu hepatocellular / drug therapy hepatocellular / metabolism* liver neoplasms / drug therapy liver neoplasms / metabolism* map kinase signaling system / drug effects* naphthoquinones / chemistry stat3 transcription factor / metabolism* p38 mitogen-activated protein kinases / metabolism*

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