cGAS drives noncanonical-inflammasome activation in age-related macular degeneration

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2018
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Abstract
Geographic atrophy is a blinding form of age-related macular degeneration characterized by retinal pigmented epithelium (RPE) death; the RPE also exhibits DICER1 deficiency, resultant accumulation of endogenous Alu-retroelement RNA, and NLRP3-inflammasome activation. How the inflammasome is activate ā€¦
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Authors Kerur N;Fukuda S;Banerjee D;Kim Y;Fu D;Apicella I;Varshney A;Yasuma R;Fowler BJ;Baghdasaryan E;Marion KM;Huang X;Yasuma T;Hirano Y;Serbulea V;Ambati M;Ambati VL;Kajiwara Y;Ambati K;Hirahara S;Bastos-Carvalho A;Ogura Y;Terasaki H;Oshika T;Kim KB;Hinton DR;Leitinger N;Cambier JC;Buxbaum JD;Kenney MC;Jazwinski SM;Nagai H;Hara I;West AP;Fitzgerald KA;Sadda SR;Gelfand BD;Ambati J;;
Journal Nature Medicine
Year 2018
DOI DOI not found
URL
https://www.pubmed.gov/29176737/
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't N.I.H. Extramural signal transduction shinichi fukuda pmid:29176737 pmc5760363 doi:10.1038/nm.4450 nagaraj kerur jayakrishna ambati dead-box rna helicases / genetics geographic atrophy / enzymology* inflammasomes / metabolism* interferon type i / metabolism nucleotidyltransferases / metabolism* retinal pigment epithelium / metabolism ribonuclease iii / genetics

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